Phenibut is a neuropyschotropic drug discovered in Russia in the late 1960’s to relieve feelings of stress and anxiety without causing loss of motor skills. In 1975 phenibut was mandated to be included in the Russian cosmonauts’ medical kit. Technically it is a designer GABA analogue and is the result of chemists adding a 6-carbon ring to the GABA supplement, thus allowing phenibut to effectively cross the blood-brain barrier and act on GABA receptors. Another interesting aspect about phenibut is it’s relationship with dopamine receptors, the neurotransmitter released during feelings of pleasure. Phenibut is actually able to increase dopamine levels in the brain. Phenibut has anxiolytic and nootropic properties and interacts with the GABA-B receptor sites. Drugs and substances such as baclofen, GHB, and alcohol also bind to these recptor sites.
Kratom is a decidious tree native to Asia, and is part of the coffee family. Mitragynine, the primary alkaloid in kratom, is an opioid agonist and 7-hyrdoxymitragynine, a secondary alkaloid of kratom, has characteristics similar to that of morphine. Both alkaloids stimulate the mu- and delta- opioid receptors in the brain, giving the plant the unique ability to alleviate pain and induce opiate-like effects. The kratom effects vary according to the strain and dosage used. Lower dosages (2-6 grams) can produce stimulating effects, while higher dosages (7-10 grams) can provide more pain relief and sedation. Kratom is divided into three spearate strains: red, white and green. The red strains are usually the most sedating, while the white strains are typically more stimulating in nature. The green kratom strains fall somewhere in the middle of the two.
The phenibut and kratom combo is often used to treat opiate withdrawal and pain relief, but also to get high(http://nootropicsrevealed.com/nootropics/mood-enhancers/phenibut/phenibut-high/). In fact, the phenibut high and unique kratom effects are quite popular and when used alone, phenibut and kratom are very effective. It is when they are used together that they offer a trruly synergistic effect that is much more powerful. While this combination is strong, it is also potentially addictive. When using them for opiate withdrawal, many users may find it hard to stop if they like the effects. Obvioulsly this is a better habit than the prior, but none the less, it should be noted that the risk for addcition is present.
Furthermore, this synergistic combo can be quite potent so that one must be careful with the dosing. Often times, less is more with these substances. Taking too much of either one, could cause a potentially dangerous experience. Using kratom and phenibut with caution should be considered best practice. For those just looking to get high, then higher doses may need to be used. Whether for medicinal or recreational use, these substances should not disappoint.